Scientists reveal unprecedented degree of connectivity reorganization in newly-generated hippocampal neurons in response to experience
05.02.2015
The hippocampus is an anatomical area of the brain classically involved in memory formation and modulation of emotional behavior. This is also one of the very few regions in the adult brain where resident neural stem cells generate new neurons life-long, thus providing the hippocampal circuitry with an almost unique renewal mechanism important for information processing and mood regulation. In response to experience and voluntary exercise, the amount of new neurons that incorporate into the hippocampus increases. Scientists from the Cologne Cluster of Excellence in Cellular Stress Responses in Aging-associated Diseases (CECAD), LMU Munich, and the University Medical Center of Johannes Gutenberg University Mainz (JGU) have joined their efforts to investigate whether experience, rather than merely promoting neurogenesis, also modifies the connectivity of new neurons.
The scientists successfully showed that the pattern of connectivity of new neurons, namely the number and types of inputs received by each new neuron, is not prefigured in the adult brain but can be significantly altered in response to complex environmental conditions. In fact, following environmental enrichment (EE) the innervation by both local hippocampal interneurons and long distance projection cortical neurons was substantially increased. However, while the inhibitory inputs were largely transient, cortical innervation remained elevated even after ending the exposure to EE. These findings reveal that exposure to complex environmental stimuli as well as their deprivation regulates the way new neurons become incorporated into the preexisting circuitry and thus their engagement into hippocampal-dependent tasks.
These findings significantly contribute to deepen our understanding of how the brain responds to experience and how external stimuli are translated into stable changes of neuronal connectivity. Their results will not only help deciphering how complex learning processes modify the brain's plasticity, but may also create an experimental basis for investigating the maladaptive changes in brain connectivity associated with neurological and neuropsychiatric disorders such as epilepsy, depression, anxiety, and posttraumatic stress. The insights provided by this study represent a crucial step towards realizing the broader vision of the Mainz University Medical Center and the German Resilience Center, namely to understand the mechanisms of resilience, i.e., an individual's ability to adapt to stress or adversity.